Fig 3.

Comparative biodistribution, replication, and elimination of HAV parental and G1217D mutant strains. (A) Percentages of initial virus inocula in the liver and spleen at different times p.i., measured via genome copies (positive-strand RNA). (B) Genome copy numbers (positive-strand RNA) in the liver at different times p.i. (C) Antigenome copy numbers (negative-strand RNA) in the liver at different times p.i. (D) Genome copy numbers (positive-strand RNA) in serum at different times p.i. (E) Genome copy numbers (positive-strand RNA) in stool at different times p.i. Different letters indicate statistically significant differences (P < 0.05). Lowercase letters indicate comparison between both strains at a given sampling time. Capital letters indicate comparison at different sampling times for a given strain.