Table 2.

Parameter estimates for the transition to genome replication

Rate constant	Valuee		Local sensitivity (%)
	In vitroa	Cell cultureb	In vitro	Cell culture
kNPBind		3.01 · 10−4		7.16 · 10−3
kRdRpBind		1c		6.62 · 10−7
kMDeg	0.37	0.33	0.13	1.37 · 10−2
kRDeg	0.06	36.36	1.76 · 10−2	1.21 · 10−5
kRRdRpDeg		4.25		1.16 · 10−2
kCSyn	0.03	0.76	8.78 · 10−2	5.31 · 10−2
kMSyn	0.21d	0.96d	0.18	8 · 10−2

^aModel fit is presented in Fig. 3A.

^bModel fit is presented in Fig. 3B to D.

^cSince polymerase binding is at saturation in experiments, we can only estimate the lower bound of this rate.

^dFor better comparison, the synthesis rate of an mRNA of average length is shown. In the model, transcription is proportional to the actual length of each segment's mRNA using a length-specific synthesis rate of 350 nt · h⁻¹ (in vitro) and 1,630 nt · h⁻¹ (cell culture).

^eValues for k_NP^Bind and k_RdRp^Bind are given in (molecules · h)⁻¹, and the other constants are given in h⁻¹.