Fig 10.

The proposed model for bmnpv-miR-1-mediated evasion of the host defense response mounted by small RNAs for effective proliferation of BmNPV in infected larvae. The model proposed here shows that BmNPV, upon infection of silkworm larvae, encodes an miRNA, bmnpv-miR-1, which represses Ran, an important component of small-RNA export from the nucleus to the cytoplasm, by binding its 3′ UTR. As a result, the small-RNA population is reduced in the cytoplasm, leading to proliferation of the virus.