Fig 12.

Replication complex in Hec1B/miR-122 replicon cells. (A) Huh7 and Hec1B/miR-122 cells harboring the Con1 SGR RNA were fixed, permeabilized, and stained with antibodies to NS5A and dsRNA or FKBP8. The boxed areas in the merged images were magnified, and the images are displayed on the right. (B) Hec1B-derived Con1 SGR cells were stained with anti-NS5A antibody. Identical fields were observed under EM by using the correlative FM-EM technique. The boxed areas are magnified, and the images displayed on the right.