Table 4.
Clinical and pathological findings in rhesus macaques infected with SHIVAD8 virus stocks
| Animal | Inoculum | Clinical data/pathological findings | No. of plateletsb (103/μl) |
|---|---|---|---|
| DB93a | SHIVAD8-CE8J | Euthanized (wk 24); rapid progressor | 29 |
| DB1Aa | SHIVAD8-CE8J | Euthanized (wk 87); arteriolopathy in kidneys and mesentery | 37 |
| CL5Ea | SHIVAD8-CE8J | Euthanized (wk 51); pulmonary thrombosis | 66 |
| DA24 | SHIVAD8-CE8J | Total CD4+ T cells, 79/mm3 (wk 94) | 223 |
| DBJE | SHIVAD8-CE8J | Total CD4+ T cells, 183/mm3 (wk 95) | 196 |
| DBZL | SHIVAD8-CE8J | Total CD4+ T cells, 796/mm3 (wk 95) | 341 |
| CZH | SHIVAD8-CE8J | Total CD4+ T cells, 106/mm3 (wk 81) | 183 |
| DBX9 | SHIVAD8-CE8J | Total CD4+ T cells, 583/mm3 (wk 81) | 423 |
| CJ7Da | SHIVAD8-CK15 | Euthanized (wk 125); enteritis | 482 |
| A3E050a | SHIVAD8-CK15 | Euthanized (wk 44); uncontrolled diarrhea | 201 |
| DC1W | SHIVAD8-CK15 | Total CD4+ T cells, 1419/mm3 (wk 94) | 464 |
| DC87 | SHIVAD8-CK15 | Total CD4+ T cells, 173/mm3 (wk 94) | 301 |
| DBRL | SHIVAD8-CK15 | Total CD4+ T cells, 211/mm3 (wk 84) | 66 |
| DC65a | SHIVAD8-CK15 | Euthanized (wk 43); Mycobacterium intracellulare | 48 |
| BIH | SHIVAD8-CK15 | Total CD4+ T cells, 312/mm3 (wk 38) | 110 |
| ENFa | SHIVAD8-CK15 | Euthanized (wk 35), Mycobacterium avium | 125 |
| CK5Ha | SHIVAD8-CL98 | Euthanized (wk 23); rapid progressor; uncontrolled diarrhea, viral enterotyphocolitis | 65 |
| A3E051a | SHIVAD8-CL98 | Euthanized (wk 125); enterotyphocolitis | 358 |
| DA55a | SHIVAD8-CL98 | Euthanized (wk 95); lymphoma | 36 |
| DB18a | SHIVAD8-CL98 | Euthanized (wk 25); Candida and Pneumocystis | 126 |
| CL5B | SHIVAD8-CL98 | Total CD4+ T cells, 696/mm3 (wk 69) | 372 |
| DB0F | SHIVAD8-CL98 | Total CD4+ T cells, 268/mm3 (wk 69) | 261 |
a
Euthanized with simian AIDS.
b
Normal range is 260 × 103 to 361 × 103/μl.