Table 2.
Susceptibilities to etravirine of WT and mutant RTs harboring the E138K mutation in different RT subunits
| RT enzyme | Mean IC50 ± SDa (nM) | Fold change in resistanceb |
|---|---|---|
| p66WT/p51WT | 186 ± 15 | |
| p66E138K/p51E138K | 669 ± 29 | 3.6 |
| p66WT/p51E138K | 651 ± 34 | 3.5 |
| p66E138K/p51WT | 204 ± 20 | 1.1 |
a
The IC50 (50% drug inhibitory concentration) values were determined by recombinant RT assays. Data represent the means ± standard deviations of data from 3 independent experiments.
b
Values represent the fold changes in IC50 values for mutated RTs compared to WT RT.