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. 2012 Aug;86(16):8422–8431. doi: 10.1128/JVI.00271-12

Table 2.

Susceptibilities to etravirine of WT and mutant RTs harboring the E138K mutation in different RT subunits

RT enzyme Mean IC50 ± SDa (nM) Fold change in resistanceb
p66WT/p51WT 186 ± 15
p66E138K/p51E138K 669 ± 29 3.6
p66WT/p51E138K 651 ± 34 3.5
p66E138K/p51WT 204 ± 20 1.1
a

The IC50 (50% drug inhibitory concentration) values were determined by recombinant RT assays. Data represent the means ± standard deviations of data from 3 independent experiments.

b

Values represent the fold changes in IC50 values for mutated RTs compared to WT RT.