Table 1.

Summary of the growth abilities of 18 ORF deletion mutants in vitro^a

VZV ORF	Growth in cell line:				HSV-1 homolog	VZV ORF function
	MeWob	ARPE-19b	SOCc	SH-SY5Yb
1	+	+	+	+	None	Transmembrane protein
2	+	+	+	+	None	Unknown
3	+	+	+	+	UL55	Unknown
7	+	+	−	−	UL51	Tegument protein with unknown functiond
8e	+	+	+	+	UL50	Deoxyuridine triphosphatase
10	+	+	−	+	UL48	Tegument protein; transactivator of immediate-early genes
11	+	+	+	+	UL47	Tegument protein with unknown functiond
12	+	+	+	+	UL46	Tegument protein with unknown functiond
13	+	+	+	+	None	Thymidylate synthase
14	+	+	−	+	UL44	Glycoprotein gC
15	+	+	+	+	UL43	Integral membrane proteind
36	+	+	+	+	UL23	Deoxypyrimidine kinase
47e	+	+	−	+	UL13	Serine-threonine kinase
57	+	+	+	+	None	Tegument protein; role in virion egress
58	+	+	+	+	UL3	Unknown
59e	+	+	+	+	UL2	Uracil-DNA glycosylase
64/69	+	+	+	+	US10	Tegument protein with unknown functiond
65	+	+	+	+	US9	Virion protein involved in axonal transportd

^aThe growth abilities of 18 dispensable deletion mutants in MeWo cells and ARPE-19 cells compared to their growth in SH-SY5Y cells and human fetal skin organ cultures (SOC). “+” denotes normal growth and “−” denotes defective or null phenotypes for the ORF deletion mutants in the respective cell type or in SOC. The ORF7 deletion mutant was the only mutant with a severe growth defect in SH-SY5Y cells.

^bResults from this study.

^cResults from previous studies.

^dPutative function based on homology.

^ePartial ORF deletion virus study included.