Table 2.
Macaque and virus | ID50 of: |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
SIVsmE660-infected macaque |
SIVsmE543-3-infected macaque |
|||||||||
Rh422 | Rh456 | RhDC6B | RhDBPX | RhDCM6 | RhDC5M | Rh703 | Rh719 | Rh735 | Rh777 | |
Rh805 | ||||||||||
H805-24w-2 | <20 | 61 | 600 | <20 | <20 | 240 | <20 | <20 | <20 | 29 |
H805-24w-3 | <20 | 139 | 829 | <20 | <20 | 140 | <20 | <20 | <20 | <20 |
H805-24w-8 | 29 | 137 | 290 | <20 | <20 | 138 | <20 | <20 | <20 | 28 |
Rh806 | ||||||||||
H806-24w-2 | 40,710 | 128,840 | 49,741 | 2,287 | 127,602 | 107,176 | 10,316 | 133,639 | 189,488 | 3,218 |
H806-24w-3 | 45,229 | 119,214 | 96,190 | 3,516 | 128,497 | 91,130 | 13,470 | 132,642 | 192,350 | 5,874 |
H806-24w-5 | 88,897 | 140,696 | 210,280 | 5,782 | 172,721 | 124,344 | 22,481 | 277,093 | 276,044 | 8,662 |
Rh807 | ||||||||||
H807-24w-4 | <20 | <20 | 326 | <20 | <20 | 73 | <20 | <20 | <20 | <20 |
H807-24w-5 | <20 | 154 | 342 | <20 | 164 | 140 | <20 | <20 | <20 | <20 |
H807-24w-7 | <20 | 26 | 261 | <20 | <20 | 359 | <20 | <20 | <20 | <20 |
Rh808 | ||||||||||
H808-24w-1 | <20 | 729 | 434 | <20 | <20 | 91 | <20 | <20 | <20 | 25 |
H808-24w-5 | 23,680 | 65,088 | 65,807 | 5,205 | 133,679 | 91,290 | 8,038 | 137,877 | 167,798 | 3,416 |
H808-24w-10 | 232 | 331 | 402 | <20 | <20 | 112 | <20 | <20 | <20 | <20 |
Controls | ||||||||||
SIVsmE660-FL6 | 53,658 | 167,359 | 82,676 | 7,327 | 118,644 | 73,426 | 14,675 | 109,311 | 243,486 | 6,908 |
SIVsmE660-FL14 | 88,656 | 775,565 | 294,326 | 22,535 | 313,521 | 507,644 | 13,155 | 251,673 | 430,011 | 6,784 |
SIVsmE543-3 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | 55 | 36 |
Neutralization antibody ID50 titers against Env clones from 24-w.p.i plasma were determined by a TZM-bl neutralization assay. Sera from six SIVsmE660-infected rhesus macaques and four SIVsmE543-3-infected macaques were used. Control viruses include the neutralization-sensitive virus clones SIVsmE660-FL6 and SIVsmE660-FL14 and the neutralization-resistant virus SIVsmE543-3.