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HRM scores and sequence-based diversity measures increase over time after infection. HRM scores and sequence-based diversity measures (percent diversity, percent complexity, and Shannon entropy) increased for both GAG (A, B, C, and D) and ENV (E, F, G, and H) over time from seroconversion. Univariate logistic regression analysis was used to calculate the mean longitudinal change (solid line) with 95% confidence intervals (dotted lines).
