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. 2012 Sep;50(9):3054–3059. doi: 10.1128/JCM.01460-12

Table 1.

Description of sequence-based diversity measures

Diversity measure Method of calculation
% diversity Average pairwise genetic distance was calculated using the maximum composite likelihood model. MEGA 5.05 (www.megasoftware.net) was used to analyze gap-stripped sequence alignments. This value is reported as a percentage.
% complexity [(no. of distinct variants)/(total no. of reads)] × 100
Shannon entropy (S) S=(1logN)i=1npilogpi
where pi is the proportion of reads consisting of each unique sequence pattern, N is the total no. of sequences, and n is the no. of distinct sequences