Table 2.
Medians and IQRs for diversity measures
| Region | Diversity measurea | At seroconversion |
Postseroconversionb |
||
|---|---|---|---|---|---|
| Median (IQR) | nc | Median (IQR) | nc | ||
| GAG | % diversity | 0.05 (0.00–0.17) | 110 | 0.28 (0.12–0.48) | 108 |
| % complexity | 0.08 (0.04–0.15) | 110 | 0.15 (0.09–0.27) | 108 | |
| Shannon entropy | 0.06 (0.02–0.11) | 110 | 0.13 (0.09–0.18) | 108 | |
| HRM score | 4.21 (3.87–4.71) | 109 | 5.03 (4.57–5.60) | 110 | |
| ENV | % diversity | 0.20 (0.05–0.47) | 109 | 0.67 (0.33–1.23) | 110 |
| % complexity | 0.12 (0.07–0.22) | 109 | 0.31 (0.15–0.59) | 110 | |
| Shannon entropy | 0.12 (0.06–0.18) | 109 | 0.21 (0.14–0.27) | 110 | |
| HRM score | 4.27 (3.96–4.76) | 108 | 4.84 (4.09–5.69) | 96 | |
a
Sequence-based diversity measures included the percent diversity, percent complexity, and Shannon entropy (Table 1); the HRM score is the output from the HRM diversity assay.
b
Postseroconversion samples were collected approximately 1 to 8 years after the seroconversion sample.
c
In some cases, NGS or HRM data could not be obtained.