Table 4.

Change in viral diversity over time^a

Region	Diversity measure	Change in measure/yr (95% CI)	P value
GAG	% diversity	0.04 (0.03, 0.06)	<0.001
	% complexity	0.02 (0.00, 0.04)	0.053
	Shannon entropy	0.01 (0.01, 0.02)	<0.001
	HRM score	0.18 (0.15, 0.22)	<0.001
ENV	% diversity	0.17 (0.13, 0.20)	<0.001
	% complexity	0.11 (0.07, 0.15)	<0.001
	Shannon entropy	0.02 (0.01, 0.03)	<0.001
	HRM score	0.17 (0.11, 0.24)	<0.001

^aResults of a linear mixed model examining the change in viral diversity per year since seroconversion in longitudinally sampled individuals. All data were removed for individuals who had dual infection at the first time point (seroconversion).