Table 5.

Relationship between the change in diversity over time measured using NGS and the change in diversity over time measured using the HRM diversity assay^a

Region	Diversity measure	Change in diversity measure (95% CI)	P value
GAG	% diversity	0.24 (0.15, 0.34)	<0.001
	% complexity	0.10 (−0.01, 0.22)	0.079
	Shannon entropy	0.06 (0.04, 0.09)	<0.001
ENV	% diversity	0.42 (0.33, 0.52)	<0.001
	% complexity	0.30 (0.15, 0.45)	<0.001
	Shannon entropy	0.05 (0.03, 0.06)	<0.001

^aResults of a simple linear regression predicting change in sequence-based diversity measures by one unit change in HRM score. All data were removed for individuals who had dual infection at the first time point (seroconversion).