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Intrathecal QX-314 did not produce overt lesions of the spinal cord. A small segment of the spinal cord near the opening of the catheter was removed, fixed and processed for histology. No obvious lesions were detected in the transverse sections of the spinal cord from animals treated with vehicle, QX-314, capsaicin, or the QX-314/capsaicin combination. Scale bar = 50 µm.
