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. 2012 Sep;56(9):4906–4913. doi: 10.1128/AAC.00987-12

Table 1.

Antibiotics screeneda

Antibiotic Initial concn (μg/ml) MIC (μg/ml)
RMC26
CT31-7d
S. Typhimurium LT2
MEP MVA MEP MVA
Ampicillin 200 2.5 2.5 NA NA 0.8–1.6
Carbenicillin 200 20 200 NA NA 100
Streptomycin 200 50 100 100 100 12.5
Neomycin 200 NA NA NA NA 25
Azithromycin 20 0.31–2.5 5–10 5 5 12.5
Clindamycin 200 0.16–0.63 2.5–5 NA NA 2.5–5
Erythromycin 200 50–100 100–200 25–50 50 100–200
Clarithromycin 200 25–50 100 25–50 50 100–200
Lincomycin 200 12.5 NA 25–50 200 NA
Tetracycline 2 0.25–0.5 0.5–2 2 2 0.5
Doxycycline 20 0.08–0.6 0.63–1.25 1.25–2.5 1.25 0.5
Trimethoprim 20 2.5 20 1.25–2.5 1.25–2.5 0.5
Chloramphenicol 20 1.25 2.5 1.25–2.5 1.25–2.5 5
Ciprofloxacin 0.08 0.005–0.01 0.01–0.02 0.01 0.01 0.02
Levofloxacin 2 0.06–0.25 0.25–0.5 0.03 0.03 0.03
Nalidixic acid 20 1.25 2.5 2.5 2.5 1.25–5
Fosfomycin 100 (-) (-) 1 1 (-)
Fosmidomycin Var. 0.2 NA 0.01 NA 10
a

MICs were determined as the lowest concentration that inhibited bacterial growth > 90%, as determined by A600 values relative to no-inhibitor control results. A minimum of 3 independent experiments, each run in duplicate, were used to determine MICs. Plates were incubated at 37°C and 80% humidity with shaking at 250 rpm. Plates were read after 18 h. NA = no activity; (-) = not screened.