Fig 1.
Extracellular and intracellular TFV pharmacokinetics following subcutaneous TFV versus oral TDF administration. (A and B) Levels of TFV in plasma and values for area under the plasma concentration-versus-time curve (AUC0–24), respectively, for day 7 and day 20 of drug administration. (C) Accumulation of TFV-DP in PBMC collected on the respective study days, exactly 24 h after the drug dosing on the previous day. (D and E) Intracellular levels of the active metabolite TFV-DP in mononuclear cells from blood or tissues at the time of euthanasia on day 21. All values are means ± SD for samples collected from four animals, except for jejunum and rectum samples from the subcutaneous-tenofovir group, where samples were collected from two animals.