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Summary of results of the in vitro resistance selection experiment with TMC647055. Shown are the frequencies of changes observed at different amino acid positions in NS5B sequences from TMC647055-treated replicon colonies or pools (21 of genotype 1a, 49 of genotype 1b). Positions at which mutations were present in at least three sequences are shown. Gray bars, genotype 1a; black bars, genotype 1b.
