Table 3.
Antiviral activity of TMC647055 against chimeric replicons containing the NS5B region derived from patient isolates assessed in a transient replicon assaya
| NS5B genotype in transient replicon | No. of isolates | Median EC50 (μM) | EC50 range (μM) |
|---|---|---|---|
| Wild-type clone ET | 0.051 | ||
| 1a | 14 | 0.048 | 0.016–0.185 |
| 1b | 10 | 0.027 | 0.014–0.051 |
| 2a | 1 | 12.530 | |
| 2b | 2 | NDb | 28.7–>98.4 |
| 3a | 2 | 0.088 | 0.050–0.127 |
| 4a | 1 | 0.097 | |
| 6a | 2 | 0.113 | 0.082–0.143 |
a
The median EC50 across the different isolates within one genotype, the number of different isolates per genotype, and the range of the EC50s of the different isolates within one genotype are shown. For n = 1 or 2, the observed value or the mean of the two observed values is, respectively, reported.
b
ND, value not determined because the median EC50 for one genotype 2b isolate was 28.7 μM and that for the other genotype 2b isolate was >98.4 μM.