Fig 2.

Kill kinetics of H. pylori ATCC 43504 by artemisinin and its five potent derivatives. Time- and dose-dependent killing of the bacteria by artemisinin derivatives GRB-1, GRB-2, GRB-3, GRB-4, and GRB-5 (panels A to E, respectively) and artemisinin (GRB-17) (F) were evaluated. The MICs of GRB-17, GRB-1, GRB-3, and GRB-4 were considered as 1 μg/ml and that of GRB-2 and GRB-5 was considered as 0.5 μg/ml. Symbols: ●, control; ○, 0.5× MIC; □, 1× MIC; △, 2× MIC; ▽, 4× MIC; ♢, 8× MIC; ⎔, 16× MIC; ✚, 32 × MIC.