Fig 5.

In vivo effect of GRB-1, dual therapy (CM [clarithromycin and metronidazole]), and triple therapy (OCM [omeprazole, clarithromycin, and metronidazole]) on H. pylori infection in C57BL/6J mice. Clearance (A) indicates reduction in bacterial load 36 h after the cessation of treatment, whereas eradication (B) indicates the same 29 days after the treatment (reduction in bacterial load in terms of 8 mice for the infection control, five each for OCM and CM, and six for GRB-1, 50 mg/kg/day). The animals were sacrificed after 36 h (4 mice for the infection control, 2 mice for OCM, 3 mice with CM and GRB-1 each) and 29 days (4 mice for the infection control, 3 mice for OCM, 2 mice for CM, and 3 mice GRB-1) after the last treatment. Each point represents the viable count obtained from each animal in the particular group.