Table 5.
Checkerboard titration assay of artemisinin and GRB-1 in combination with antibioticsa
| FIC index (interpretation) | No. (%) of isolates |
|||||
|---|---|---|---|---|---|---|
| GRB-17 (artemisinin) |
GRB-1 |
|||||
| CLR | AMX | MNZ | CLR | AMX | MNZ | |
| ≤0.5 (synergy) | 0 | 0 | 0 | 0 | 1 (10) | 0 |
| >0.5 to ≤4.0 (nonsynergistic) | 10 (10) | 10 (10) | 10 (10) | 10 (10) | 9 (10) | 10 (10) |
| >4.0 (antagonism) | 0 | 0 | 0 | 0 | 0 | 0 |
a
Checkerboard titration for determining synergism between artemisinin (GRB-17) or GRB-1 with standard antibiotics against 10 H. pylori strains was performed using a broth microdilution assay.