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Structures of tipifarnib and analogs with potent anti-T. cruzi activity. Compound 1 exhibits atropisomerism around the bond marked with the arrow. Compounds 2 and 3 solve the rotamer problem while retaining highly potent T. cruzi activity and low human PFT inhibition. The crystal structure of Trypanosoma brucei CYP51 was solved with compound 3. The structure of posaconazole is provided for comparison. amast., amastigotes.
