Table 1.

Pharmacokinetic parameters following oral administration of compound 2 and posaconazole to mice

Parameterc	Compound 2		Posaconazole
	Day 1a	Estimated day 20b	Day 1a	Estimated day 20b
Dose (mg/kg)	40	40	20	20
Cmax (μM)	4.7	4.8	14.3	48.2
dn-Cmax (μM/mg/kg)	0.1	0.1	0.7	2.4
AUC0–∞ (μM · h)	22.9	23.3	509	1700
dn-AUC0–∞ (μM · h/mg/kg)	0.57	0.58	25.5	85.0
Cav,ss (μM)	1.9	1.9	42.4	141

^aDay 1 data were based on the fit of a single-compartment pharmacokinetic model to experimental single-oral-dose data.

^bDay 20 b.i.d. data (after the second dose on day 20) were estimated using simulated profiles based on the fitted data after a single dose.

^cdn, dose normalized.