Table 2.

Efficacy experiment with mice infected with Trypanosoma cruzi Y strain and treated daily with compound 2, posaconazole, or benznidazole for 20 consecutive days^a

Parameter	Treatment group
	Compound 2 (40 mg/kg)	Posaconazole (20 mg/kg)	Benznidazole (100 mg/kg)
No. of drug doses for clearance of parasitemia (mean ± SD)	1.71 ± 1.11	1.5 ± 0.58	1.17 ± 0.41
No. of mice with natural parasitemia reactivation after treatment/total no.	4/5	0/5	1/6
No. of mice with parasitemia reactivation after immunosuppression/total no.	3/5	0/5	1/6
No. of mice positive by real-time PCRb (30 days after treatment)/total no.	5/5	2/5	2/6
Total no. of positive mice/total no.	5/5	2/5	2/6

^aTreatments were started at the 4th day after infection.

^bReal-time PCR was performed in blood of all animals 30 days after treatment.