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Brief exposure to caspofungin results in redistribution of PI(4,5)P2 and septins to aberrant patches in wild-type C. albicans cells. A 5-min exposure to caspofungin at the MIC (0.125 μg/ml) did not kill a wild-type C. albicans strain (A) but resulted in redistribution of CaPH-GFP (B) and Cdc10-RFP (C) to aberrant patches (D, overlay image). PI(4,5)P2-septin colocalization was similar to that seen in irs4, inp51, and gin4 mutant cells in the absence of cell wall stress.
