Table 2.
Results of noncompartmental analysis of PK parameters in the short- and prolonged-infusion groupsa
| Parameterb | Group 1 | Group 2 | P value |
|---|---|---|---|
| Actual meropenem dose (mg/kg) | 18.9 (5) | 18.3 (2.4) | 0,650 |
| t1/2 (h) | 3.4 (0.9) | 3.3 (1.7) | 0.436 |
| Cmax (mg/liter) | 89.3 (32.7) | 54.5 (19.0) | 0.005 |
| Tmax (h) | 0.7 (0.4) | 4.0 (1.9) | 0.002 |
| Cmin (mg/liter) | 6.5 (3.7) | 7.2 (6.1) | 0.780 |
| CLssM (ml/h/kg) | 52.4 (15.5) | 62.7 (31.6) | 0.842 |
| Vss (ml/kg) | 270.6 (83.3) | 342.9 (174.3) | 0.447 |
| AUClastc (h · μg/ml) | 369.2 (66.1) | 338.6 (121.6) | 0.497 |
| fT>MIC (%)d (95% CI) | 100 (100–100) | 99.9 (99.6–100) | 0.193 |
a
Groups: 1, short infusion; 2, prolonged infusion. Data are presented as means (SD) if not stated otherwise.
b
t½, half-life.
c
AUClast, area under the concentration-time curve from time zero to the last point of the curve.
d
Calculated for the EUCAST MIC susceptibility breakpoint of 2 mg/liter for P. aeruginosa and Enterobacteriaceae.