Table 2.

Enterobacteriaceae strains carrying more than one β-lactamase gene

No. of enzymes	Enzymea										No. of strains	Fold (log2) reduction in the ceftaroline MIC in the presence of 4 μg/ml avibactamb
	ESBL					Non-ESBL			Plasmid AmpC	KPC
	CTX-M	SHV	GES	OXA	OXY	SHV	TEM	OXA
2	X							X			3	256–2,048
2	X					X					5	512–8,192
2	X						X				7	512–8,192
2		X						X			3	32–8,192
2							X	X			2	64–2,048
2					X			X			1	2,048
2		X					X				1	4,096
2						X	X				1	512
2						X		X			2	32–8,192
2c	X										2	4–128
2c		X									15	16–1,024
2c			X								1	512
2c				X							1	512
3	X	X						X			1	8,192
3	X			X			X				1	4,096
3	X	X					X				1	8,192
3	X					X	X				4	512–4,096
3	X						X	X			1	512
3		X					X	X			1	256
3						X	X	X			2	2,048–8,192
3		X			X		X				1	512
3c	X						X				1	1,024
3c		X						X			5	32–2,048
4c		X					X	X			2	128–512
2						X				X	1	512
3		X			X					X	1	1,024
3		X						X		X	1	512
3						X		X		X	1	256
3						X	X			X	3	512–1,024

^aThe presence of a particular enzyme is indicated by the letter X.

^bOff-scale results were represented by the immediately higher dilution concentration.

^cIncluding species that putatively have derepressed AmpC.