Table 4.
Mean histopathologic scores of tedizolid phosphate and linezolid in lung tissue of mice with S. pneumoniae pneumonia at 48 h postinfection
| Antimicrobial agent (regimen)a | Inflammation scoreb | Edema scoreb |
|---|---|---|
| Tedizolid phosphate (10 mg/kg QD) | 1.0 | 0.5 |
| Linezolid (5 mg/kg BID) | 2.1 | 1.9 |
| Untreated control | 2.6 | 1.1 |
| Uninfected control | 0 | 0 |
a
Oral antimicrobial treatment was initiated at 4 h postinfection.
b
Inflammation and edema were each graded on a scale of from 0 to 3 (0, absent; 1, mild; 2, moderate; and 3, severe).