Fig 6.

In vivo activity of M131 combinations with imipenem on MRSA infection. (A) MRSA COL deep-thigh infection model. (B) MRSA COL systemic infection model. Both assays are performed with neutropenic female BALB/c mice. A single intraperitoneal dose of test agents were applied 2 h postinfection for the thigh model and 30 min postinfection for the bacteremia model. Linezolid (Lin) was employed as a positive control and dosed orally (20 mg/kg) at 2 h and 8 h postinoculation. Results are plotted as means of bacterial counts in infected tissue (n = 5); the error bars represent standard deviations. The dashed lines indicate the bacterial counts recovered from vehicle-treated MRSA-infected mice. Statistical significance was determined by one-way ANOVA with Bonferroni posttest: ϕ, P values of <0.05 for comparisons with uninfected mice; *, P values of <0.05 for comparisons with vehicle-treated mice.