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Inhibition of SpsB enzymatic activity and β-lactamase secretion by SpsB inhibitors
| Compound | IC50 (nM) |
|
|---|---|---|
| SpsB enzymatic activity | β-Lactamase secretiona | |
| Krisynomycin | 120 | 7 |
| Actinocarbasin | 50 | 3 |
| M131 | 10 | 2 |
Values are on average more than three orders of magnitude lower than IC50s for inhibition of bacterial growth, as determined side by side in the same experiment.
