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. 2012 Jul;14(7):624–633. doi: 10.1593/neo.12486

Figure 1.

Figure 1

Higher levels of COX-2 expression are seen in CRC cells. Levels of COX-1 and COX-2 were assessed in sensitive MIP101 and resistant MIP/5-FU cells (A) or sensitive RKO and resistant RKO/5-FU cells (B) by reverse transcription-polymerase chain reaction. The effects of aspirin or celecoxib exposures on COX-2 protein expression were also examined in MIP101 and MIP/5-FU (C) and RKO and RKO/5-FU cells (D) by immunoblot analysis. Clonogenic assays showing MIP/5-FU cells incubated with 1.8 mM aspirin (E) or 30 µM celecoxib (F) and exposed to 5-FU for 7 days. All results represent mean ± SE (n > 3 independent studies). ASA indicates aspirin; Cxb, celecoxib.