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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Dev Dyn. 2012 Apr;241(4):732–740. doi: 10.1002/dvdy.23764

Figure 1. Effect of SU5402 on cell signaling and survival.

Figure 1

(A) In control embryos that were sectioned sagitally (n=6), immunohistochemistry reveals the presence of pERK throughout the face and brain at HH 15. (B) At this time, embryos treated with SU5402 exhibit decreased pERK staining (n=6). (C) Similarly, control embryos exhibit high levels of pMEK (n=6), and (D) treated embryos have reduced expression levels (n=6). (E) In medial sections, TUNEL staining revealed apoptotic cells (bright green dots) in the brain of control embryos (n=8) and (F) treated embryos (n=12) at HH15. (G) Cell death in lateral regions of control embryos was not apparent (n=8), but (H) in treated embryos large regions of apoptotic mesenchyme was evident (n=12). Scale bars: 200μm.