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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: J Am Chem Soc. 2012 Jul 19;134(30):12402–12405. doi: 10.1021/ja305113d

Scheme 2. Reagents and Conditions.

Scheme 2

(a) NBS, dibenzoyl peroxide, CCl4, reflux, 1h, 70%; (b) NaHCO3, H2O, Me2CO, reflux, 4h, 86%; (c) PCC, silica gel, CH2Cl2, 1h, quant.; (d) 1M BBr3 in CH2Cl2, 2h; (e) 1:1 HCl:AcOH, reflux, 10h, 60%; (f) 1,3-propanediol, TsOH (cat.), toluene, reflux, 12h, 75%; (g) chloro-methyl methyl ether, iPr2EtN, CH2Cl2, 40 °C, 24h, 95%; (h) n-BuLi, n-Bu3SnCl, hexane, 0°C, 88%; (i) Pd2(dba)3•CHCl3, PPh3, CuI, THF, 75 °C, 12h, 75%; (j) 2.4 M HCl in CH3CN, 74%.