Figure 2.

 Signal strength model for memory T‐cell generation. Upon activation, naive CD8⁺ T cells develop into either central memory T cells (T_CM) or effector memory T cells (T_EM). As indicated T_CM and T_EM cells are distinguishable based on their phenotype, function, and anatomical location. The T_CM and T_EM fate decision occurs early during priming, determined by antigen access and/or dose. Brief periods of antigenic stimulation or antigen availability during priming favor the enrichment of T_CM cells, whereas prolonged periods support T_EM cell generation. T_EM and T_CM have the ability to interchange phenotype, dictated by the presence or absence of antigen. Modified from (46).