Table 1.
Haemodynamic data
| Variable | Pre-ischaemia | End ischaemia | Reperfusion (min) |
|||
|---|---|---|---|---|---|---|
| 30 | 60 | 120 | ||||
| DVMN silencing experiment | ||||||
| DVMN neurones expressing eGFP | ||||||
| Allatostatin + sham-RPc (n = 7) | MAP | 106 ± 7 | 101 ± 7 | 96 ± 6 | 92 ± 5 | 91 ± 4 |
| HR | 408 ± 8 | 411 ± 9 | 389 ± 10 | 393 ± 10 | 405 ± 9 | |
| Allatostatin + RPc (n = 8) | MAP | 111 ± 11 | 108 ± 13 | 104 ± 8 | 101 ± 6 | 96 ± 7 |
| HR | 427 ± 8 | 429 ± 10 | 422 ± 8 | 427 ± 9 | 420 ± 10 | |
| DVMN neurones expressing AlstR | ||||||
| Allatostatin + sham-RPc (n = 7) | MAP | 115 ± 9 | 104 ± 10 | 99 ± 8 | 91 ± 7 | 82 ± 7 |
| HR | 401 ± 9 | 421 ± 13 | 397 ± 12 | 384 ± 12 | 387 ± 13 | |
| Allatostatin + RPc (n = 8) | MAP | 117 ± 9 | 103 ± 7 | 102 ± 5 | 101 ± 5 | 97 ± 6 |
| HR | 413 ± 15 | 430 ± 9 | 405 ± 7 | 407 ± 7 | 409 ± 10 | |
| Optogenetic preconditioning experiment | ||||||
| DsRed—DVMN blue light (n = 7) | MAP | 92 ± 9 | 82 ± 7 | 78 ± 3 | 77 ± 5 | 80 ± 5 |
| HR | 401 ± 12 | 403 ± 8 | 384 ± 5 | 380 ± 7 | 388 ± 8 | |
| CHIEFtdTomato—DVMN blue light (n = 6) | MAP | 99 ± 6 | 79 ± 4 | 78 ± 4 | 80 ± 5 | 83 ± 4 |
| HR | 420 ± 6 | 415 ± 8 | 402 ± 7 | 397 ± 9 | 393 ± 9 | |
| DsRed—DVMN blue light + atropine (n = 7) | MAP | 106 ± 11 | 85 ± 5 | 90 ± 4 | 90 ± 7 | 80 ± 7 |
| HR | 391 ± 17 | 392 ± 11 | 393 ± 10 | 410 ± 12 | 402 ± 11 | |
| CHIEFtdTomato—DVMN blue light + atropine (n = 8) | MAP | 99 ± 10 | 76 ± 6 | 84 ± 5 | 79 ± 4 | 71 ± 3 |
| HR | 379 ± 14 | 392 ± 15 | 389 ± 11 | 380 ± 20 | 384 ± 10 | |
AlstR, allatostatin receptor; DVMN, dorsal motor nucleus of the vagus nerve; eGFP, enhanced green fluorescent protein; HR, heart rate (min−1); MAP, mean arterial blood pressure (mmHg); RPc, remote preconditioning.