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. Author manuscript; available in PMC: 2013 May 22.
Published in final edited form as: Circulation. 2012 Apr 23;125(20):2414–2416. doi: 10.1161/CIRCULATIONAHA.112.106377

Figure 1.

Figure 1

The figure illustrates the accumulation (established or potential) of proteins at the interface between adjacent platelets within a growing hemostatic plug. It also shows some of the signaling events downstream of thrombin and collagen receptors in platelets, and the stimulation and inhibition of cAMP formation in response to PGI2 and ADP. Finally, the figure illustrates one of the hypotheses discussed in the text, which is that channels formed by Cx37 are able to pass small molecules between platelets once stable contacts have formed.