FIG. 3.

Cell transplantation. 1 × 10⁶/mouse of WB (control, n = 3), WB-1 (n = 6), or INS-1 (n = 4) cells were implanted under the left renal subcapsule after the blood glucose levels reached 400 mg/dl (arrow, transplantation [Tx]) in repeatedly low-dose STZ-induced diabetic NOD-scid mice. The blood glucose levels were monitored regularly under nonfasting conditions through tapping the tail vein. The left kidney of three mice from the WB-1 group was removed at 40 days post-implantation (arrow, explanted [Ex]). The remaining WB-1– and INS-1–transplanted mice were terminated by the end of the observation (4 months).