Table 2. List of the phosphorylated molecules involved in representative glioblastoma-related signaling pathways classified by DAVIDa.
| Pathway | Protein name | Gene symbol |
| Notch signaling pathway | ADAM metallopeptidase domain 17 | ADAM17 |
| E1A binding protein p300 | EP300 | |
| SNW domain containing 1 | SNW1 | |
| corepressor interacting with RBPJ | CIR1 | |
| deltex 3-like (Drosophila) | DTX3L | |
| dishevelled, dsh homolog 3 (Drosophila) | DVL3 | |
| histone deacetylase 1 | HDAC1 | |
| histone deacetylase 2 | HDAC2 | |
| mastermind-like 2 (Drosophila) | MAML2 | |
| nuclear receptor co-repressor 2 | NCOR2 | |
| numb homolog (Drosophila)-like | NUMBL | |
| presenilin 1 | PSEN1 | |
| presenilin 2 (Alzheimer disease 4) | PSEN2 | |
| ErbB signaling pathway | BCL2-associated agonist of cell death | BAD |
| Cas-Br-M (murine) ecotropic retroviral transforming sequence | CBL | |
| Cas-Br-M (murine) ecotropic retroviral transforming sequence b | CBLB | |
| GRB2-associated binding protein 1 | GAB1 | |
| NCK adaptor protein 1 | NCK1 | |
| NCK adaptor protein 2 | NCK2 | |
| PTK2 protein tyrosine kinase 2 | PTK2 | |
| SHC (Src homology 2 domain containing) transforming protein 1 | SHC1 | |
| SHC (Src homology 2 domain containing) transforming protein 3 | SHC3 | |
| c-abl oncogene 1, receptor tyrosine kinase | ABL1 | |
| calcium/calmodulin-dependent protein kinase II delta | CAMK2D | |
| calcium/calmodulin-dependent protein kinase II gamma | CAMK2G | |
| cyclin-dependent kinase inhibitor 1B (p27, Kip1) | CDKN1B | |
| epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | EGFR | |
| eukaryotic translation initiation factor 4E binding protein 1 | EIF4EBP1 | |
| glycogen synthase kinase 3 beta | GSK3B | |
| hypothetical LOC100271831; mitogen-activated protein kinase 3 | MAPK3 | |
| jun oncogene | JUN | |
| mitogen-activated protein kinase 1 | MAPK1 | |
| mitogen-activated protein kinase kinase 2 pseudogene; mitogen-activated protein kinase kinase 2 | MAP2K2 | |
| mitogen-activated protein kinase kinase 7 | MAP2K7 | |
| p21 protein (Cdc42/Rac)-activated kinase 2 | PAK2 | |
| p21 protein (Cdc42/Rac)-activated kinase 4 | PAK4 | |
| protein kinase C, alpha | PRKCA | |
| protein kinase C, beta | PRKCB | |
| signal transducer and activator of transcription 5B | STAT5B | |
| v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) | ABL2 | |
| v-akt murine thymoma viral oncogene homolog 1 | AKT1 | |
| v-akt murine thymoma viral oncogene homolog 2 | AKT2 | |
| v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | AKT3 | |
| v-crk sarcoma virus CT10 oncogene homolog (avian) | CRK | |
| v-crk sarcoma virus CT10 oncogene homolog (avian)-like | CRKL | |
| v-raf murine sarcoma 3611 viral oncogene homolog | ARAF | |
| v-raf murine sarcoma viral oncogene homolog B1 | BRAF | |
| v-raf-1 murine leukemia viral oncogene homolog 1 | RAF1 | |
| v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | SRC | |
| mTOR signaling pathway | 3-phosphoinositide dependent protein kinase-1 | PDPK1 |
| RPTOR independent companion of MTOR, complex 2 | RICTOR | |
| eukaryotic translation initiation factor 4E binding protein 1 | EIF4EBP1 | |
| eukaryotic translation initiation factor 4E family member 2 | EIF4E2 | |
| hypothetical LOC100271831; mitogen-activated protein kinase 3 | MAPK3 | |
| mitogen-activated protein kinase 1 | MAPK1 | |
| protein kinase, AMP-activated, alpha 1 catalytic subunit | PRKAA1 | |
| regulatory associated protein of MTOR, complex 1 | RPTOR | |
| ribosomal protein S6 kinase, 90 kDa, polypeptide 1 | RPS6KA1 | |
| ribosomal protein S6 kinase, 90 kDa, polypeptide 3 | RPS6KA3 | |
| ribosomal protein S6 pseudogene 25; ribosomal protein S6; ribosomal protein S6 pseudogene 1 | RPS6 | |
| serine/threonine kinase 11 | STK11 | |
| similar to eukaryotic translation initiation factor 4H; eukaryotic translation initiation factor 4B | EIF4B | |
| tuberous sclerosis 1 | TSC1 | |
| tuberous sclerosis 2 | TSC2 | |
| v-akt murine thymoma viral oncogene homolog 1 | AKT1 | |
| v-akt murine thymoma viral oncogene homolog 2 | AKT2 | |
| v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | AKT3 | |
| v-raf murine sarcoma viral oncogene homolog B1 | BRAF | |
| Glioma | SHC (Src homology 2 domain containing) transforming protein 1 | SHC1 |
| SHC (Src homology 2 domain containing) transforming protein 3 | SHC3 | |
| calcium/calmodulin-dependent protein kinase II delta | CAMK2D | |
| calcium/calmodulin-dependent protein kinase II gamma | CAMK2G | |
| epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | EGFR | |
| hypothetical LOC100271831; mitogen-activated protein kinase 3 | MAPK3 | |
| mitogen-activated protein kinase 1 | MAPK1 | |
| mitogen-activated protein kinase kinase 2 pseudogene; mitogen-activated protein kinase kinase 2 | MAP2K2 | |
| platelet-derived growth factor receptor, alpha polypeptide | PDGFRA | |
| protein kinase C, alpha | PRKCA | |
| protein kinase C, beta | PRKCB | |
| retinoblastoma 1 | RB1 | |
| tumor protein p53 | TP53 | |
| v-akt murine thymoma viral oncogene homolog 1 | AKT1 | |
| v-akt murine thymoma viral oncogene homolog 2 | AKT2 | |
| v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | AKT3 | |
| v-raf murine sarcoma 3611 viral oncogene homolog | ARAF | |
| v-raf murine sarcoma viral oncogene homolog B1 | BRAF | |
| v-raf-1 murine leukemia viral oncogene homolog 1 | RAF1 | |
| Cell Cycle | CHK1 checkpoint homolog (S. pombe) | CHEK1 |
| E1A binding protein p300 | EP300 | |
| MAD1 mitotic arrest deficient-like 1 (yeast) | MAD1L1 | |
| S-phase kinase-associated protein 1 | SKP1 | |
| S-phase kinase-associated protein 2 (p45) | SKP2 | |
| SMAD family member 2 | SMAD2 | |
| WEE1 homolog (S. pombe) | WEE1 | |
| anaphase promoting complex subunit 1; similar to anaphase promoting complex subunit 1 | ANAPC1 | |
| anaphase promoting complex subunit 4 | ANAPC4 | |
| ataxia telangiectasia and Rad3 related; similar to ataxia telangiectasia and Rad3 related protein | ATR | |
| budding uninhibited by benzimidazoles 1 homolog (yeast) | BUB1 | |
| c-abl oncogene 1, receptor tyrosine kinase | ABL1 | |
| cell division cycle 16 homolog (S. cerevisiae) | CDC16 | |
| cell division cycle 2, G1 to S and G2 to M | CDK1 | |
| cell division cycle 23 homolog (S. cerevisiae) | CDC23 | |
| cell division cycle 25 homolog B (S. pombe) | CDC25B | |
| cell division cycle 26 homolog (S. cerevisiae); cell division cycle 26 homolog (S. cerevisiae) pseudogene | CDC26 | |
| cyclin-dependent kinase 2 | CDK2 | |
| cyclin-dependent kinase 7 | CDK7 | |
| cyclin-dependent kinase inhibitor 1B (p27, Kip1) | CDKN1B | |
| glycogen synthase kinase 3 beta | GSK3B | |
| histone deacetylase 1 | HDAC1 | |
| histone deacetylase 2 | HDAC2 | |
| minichromosome maintenance complex component 2 | MCM2 | |
| minichromosome maintenance complex component 3 | MCM3 | |
| minichromosome maintenance complex component 6 | MCM6 | |
| pituitary tumor-transforming 1; pituitary tumor-transforming 2 | PTTG2 | |
| protein kinase CHK2-like; CHK2 checkpoint homolog (S. pombe); similar to hCG1983233 | CHEK2 | |
| retinoblastoma 1 | RB1 | |
| similar to 14-3-3 protein epsilon (14-3-3E) (Mitochondrial import stimulation factor L subunit) (MSF L); | YWHAE | |
| tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | ||
| similar to Serine-protein kinase ATM (Ataxia telangiectasia mutated) (A-T, mutated); ataxia telangiectasia mutated | ATM | |
| stromal antigen 2 | STAG2 | |
| structural maintenance of chromosomes 3 | SMC3 | |
| tumor protein p53 | TP53 | |
| tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | YWHAZ |
a
http://david.abcc.ncifcrf.gov/home.jsp.