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A. Distance traveled (average cm per 2 min bin) as a function of cocaine dose in the presence and absence (control) of cocaine hydrolase (CocH, 1 mg/kg, i.p). All groups, n = 12 (means ± SEM). B. Distance traveled after a fixed dose of cocaine (40 mg/kg i.p.) as function of enzyme dose (mg/kg). Group sizes, N = 4 to12 (numbers in parenthesis).
