Figure 3. Combined anti-cocaine antibody and cocaine hydrolase block mouse locomotor stimulation by high-dose cocaine.

Untreated mice were given only i.p. saline. All others received cocaine, total of 120 mg/kg i.p., in two 60 mg/kg doses 10 min apart. CocH groups received enzyme, 1 mg/kg, i.p. AB mice received anti-cocaine antibody, 16 mg/kg i.p. “Vaccine" mice were each immunized with 100 µg of norcocaine-conjugate cocaine vaccine, and a booster immunization at 3 weeks. Statistical significance (n = 8 for all groups): * p<0.05; ** p<0.01).