Figure 6. Combined vaccine and vector treatment reduces cocaine-induced locomotor activity even after repeated cocaine injections.

Shown are beam breaks per 5 min interval (mean ± SEM). Left panels: initial two days of training phase. Middle panels: last day of training phase. Right panels: both days of challenge phase. Statistical significance: * significantly higher locomotor activity after cocaine injections compared to saline (p<0.05); & significantly higher cocaine-induced locomotor activity than in the VAC+VEC group (p<0.01); @ significantly higher cocaine-induced locomotor activity after the last cocaine injection compared to first injection (p<0.01); # significantly greater cocaine-induced locomotor activity in control group compared to all others (p<0.05).