Figure 7. The anti-immobility effect of 5-HT1B receptor agonist in the TST.

WT and snGSK3β-KO mice were treated with anpirtoline (4 mg/kg, i.p.) or saline for 30 min before they were subject to the TST. Immobility time was recorded and expressed by each 2 min blocks (left panel) and by the last 4 min of the 6-min test (right panel). n = 8–12 in each treatment group. Immobility time was recorded and expressed by the last 4 min of the 6-min test. Mean ± SEM, n = 5–6 in each treatment group. *p<0.05 in LSD post hoc of two way ANOVA when treatment was compared to baseline in the same genotypes, ^§ p<0.05 in LSD post hoc of two way ANOVA when treatment in snGSK3β-KO mice was compared to the same treatment in WT mice.