Figure 1. Comparison of the hippocampal cytoarchitecture via Nissl staining between an intact middle-aged animal (A1) and a middle-aged animal that underwent acute seizure (AS) activity (B1).

The hippocampal section illustrated in B1 is visualized at 13 days after kainic acid induced AS activity. Figures A2–A4 and B2–B4 show magnified views of marked regions of the DH (A2, B2), the CA1 subfield (A3, B3) and the CA3 subfield (A4, B4) from figures A1 and B1 respectively. Note that considerable neurodegeneration is apparent in the DH (B2), the CA3c subregion (B2) and the CA1 cell layer (B3) of the middle-aged animal that underwent AS activity. Scale bar, A1, B1 = 500 µm; A2, A4, B2, B4 = 200 µm; A3, B3 = 100 µm.