Table 1. Effect of specific antagonists on inotropic response, muscle hypertrophy, and ERK1/2 phosphorylation in 24-hr endothelin-1 treated trabeculae.

Specific antagonists	Inotropic effect	Hypertrophy	phospho-ERK1/2
KB-R7943NCX inhibitor	Inhibit	Inhibit	No
KN-93CaMKII inhibitor	Inhibit	Inhibit	No
PD98095MAPKK inhibitor	Inhibit	Inhibit	Inhibit
Cyclosporin ACalcineurin inhibitor	No	Inhibit	No
INCA6Inhibiton of NFAT-calcineurin association	Inhibit	Inhibit	No
2-APBIP3 receptor blocker	Inhibit	No	Inhibit
GF109203XNon-specific PKC inhibitor	Inhibit *	No	No
Akt inhibitor	No	No	Inhibit
T-0156Phosphodiesterase type-5 inhibitor	No	No	No

^*GF109203X induced a significant increase in developed force within 1 hour of incubation.