Figure 4. Effect of differential proliferation and mechanical forces.

(A) With differential proliferation alone, the average number of sides of IP cells decreases to a limited extent (red), and the average number of sides of IQ cells increases (blue). (B) Change in the average number of sides with different tension coefficients. Increased tension coefficients (1.5, 2.0) on the boundary lead to further reduced average number of sides of IP cells. Decreased tension coefficient (0.5) results in increased average number of sides of IP cells.