Table 2. Early Phase Significantly Perturbed Pathways Bayesian z-Scores.

Activated Pathways	t = 30	t = 60	Activated Pathways (con't)	t = 30	t = 60	Suppressed Pathways	t = 30	t = 60
Parkinson's disease	4.61	−0.31	C21-Steroid hormone metabolism	2.84	−0.06	Peptidoglycan biosynthesis	−1.55	−2.65
Porphyrin and chlorophyll metabolism	4.35	0	Tyrosine metabolism	2.84	−0.23	Lysine biosynthesis	−2.28	0
Complement and coagulation cascades	3.77	−1	PPAR signaling pathway	2.82	−0.81	*Tight junction	−2.28	−0.77
Wnt signaling pathway	3.59	0.9	*Androgen and estrogen metabolism	2.79	−0.57	Thyroid cancer	−2.36	−1.33
*Histidine metabolism	3.57	−0.38	Lysine degradation	2.77	−0.49	*Trefoil Factors Initiate Mucosal Healing	−2.36	0.23
Pyruvate metabolism	3.49	0.04	Bile acid biosynthesis	2.76	−0.1	Cell Communication	−2.37	−1.21
Olfactory transduction	3.39	0	*Glycosphingolipid biosynthesis - globoseries	2.74	1.34	Endometrial cancer	−2.45	1.82
Tetrachloroethene degradation	3.32	0.88	Acute myeloid leukemia	2.73	−1.07	*Pentose phosphate pathway	−2.46	−2.06
Hematopoietic cell lineage	3.32	−0.42	Fructose and mannose metabolism	2.71	−2.96	C5-Branched dibasic acid metabolism	−2.55	0
CD40L Signaling Pathway	3.28	0	*Aminophosphonate metabolism	2.7	0	DNA polymerase	−2.56	0.03
microtubule-associated protein 1A	3.27	−0.1	GnRH signaling pathway	2.7	−0.44	Anthrax Toxin Mechanism of Action pathway	−2.57	0
*Phosphatidylinositol signaling system	3.26	−0.2	*Caprolactam degradation	2.66	0	Basal cell carcinoma	−2.58	−1.26
Gap junction	3.23	−0.91	Adipocytokine signaling pathway	2.54	0	Fatty acid elongation in mitochondria	−2.62	0.67
Propanoate metabolism	3.22	0	*Urea cycle and metabolism of amino groups	2.54	0	Axon guidance	−2.64	−0.92
Starch and sucrose metabolism	3.17	−0.42	Toll-like receptor signaling pathway	2.51	−1.26	Reductive carboxylate cycle (CO2 fixation)	−3.02	0.82
Cytokine-cytokine receptor interaction	3.16	−0.6	*Nicotinate and nicotinamide metabolism	2.49	−0.83	*Glyoxylate and dicarboxylate metabolism	−3.14	1.67
Retinol metabolism	3.16	−0.57	Pentose and glucuronate interconversions	2.48	−0.48	Pathogenic Escherichia coli infection	−3.15	0.01
Folate biosynthesis	3.14	0.8	*beta-Alanine metabolism	2.44	0	One carbon pool by folate	−3.18	1.99
*Tryptophan metabolism	3.12	1.31	*Lectin Induced Complement Pathway	2.43	−0.31	Long-term potentiation	−3.29	1.24
Glycine, serine and threonine metabolism	3.05	−0.56	Butanoate metabolism	2.42	0.65	Citrate cycle (TCA cycle)	−3.3	0.59
*Huntington's disease	3.04	−0.16	Glycolysis/Gluconeogenesis	2.4	−0.78	Melanogenesis	−3.49	−0.97
Inositol phosphate metabolism	3.02	0	Arachidonic acid metabolism	2.39	−1.5	*Long-term depression	−3.51	−0.22
*Biosynthesis of unsaturated fatty acids	2.97	1.54	Purine metabolism	2.37	0.26	*CCR3 signaling in Eosinophils pathway	−3.51	0.96
*Selenoamino acid metabolism	2.93	−1.64	Methionine metabolism	2.35	−1.2	Oxidative phosphorylation	−3.57	−0.98
Metabolism of xenobiotics by cytochrome P450	2.91	−1.07	Ether lipid metabolism	2.33	0	Fatty acid biosynthesis	−4.02	1.76
Neuroactive ligand-receptor interaction	2.87	−1.27	Arginine and proline metabolism	2.33	−0.1
Calcium signaling pathway	2.87	−0.11	*Ascorbate and aldarate metabolism	2.33	−0.97
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis	2.85	0	*Glycerophospholipid metabolism	2.29	0