Table 4. Late Phase Significantly Perturbed Pathways Bayesian z-Scores.

Activated Pathway Description	t = 720	Activated Pathway Description (con't)	t = 720	Suppressed Pathway Description	t = 720
Fructose and mannose metabolism	3.54	Type I diabetes mellitus	2.74	*ABC transporters	−2.25
Cytokine-cytokine receptor interaction	3.4	DNA polymerase	2.73	*B cell receptor signaling pathway	−2.25
Complement and coagulation cascades	3.37	*N-Glycan biosynthesis	2.73	*Non-small cell lung cancer	−2.25
Hedgehog signaling pathway	3.3	RNA polymerase	2.73	*Chronic myeloid leukemia	−2.26
*Biosynthesis of steroids	3.29	Gap junction	2.72	*Melanoma	−2.28
Riboflavin metabolism	3.26	*Type II diabetes mellitus	2.72	*Renal cell carcinoma	−2.28
*Circadian rhythm	3.24	Inositol metabolism	2.71	*Biotin metabolism	−2.29
Starch and sucrose metabolism	3.23	*mTOR signaling pathway	2.7	*Terpenoid biosynthesis	−2.29
*Alzheimer's disease	3.22	PPAR signaling pathway	2.66	*VEGF signaling pathway	−2.31
Melanogenesis	3.21	ErbB signaling pathway	2.64	*Valine, leucine and isoleucine biosynthesis	−2.32
One carbon pool by folate	3.21	*Taste transduction	2.64	*Linoleic acid metabolism	−2.37
Wnt signaling pathway	3.15	Tyrosine metabolism	2.64	*Aminoacyl-tRNA biosynthesis	−2.39
TGF-beta signaling pathway	3.08	*Sphingolipid metabolism	2.63	*Glioma	−2.4
Basal cell carcinoma	3.07	*Cell adhesion molecules (CAMs)	2.56	Small cell lung cancer	−2.42
*Aminosugars metabolism	3.06	Phenylalanine metabolism	2.55	*Colorectal cancer	−2.43
Cell Communication	3.06	*Epithelial cell signaling Helicobacter pylori infection	2.53	Proteasome	−2.45
Long-term potentiation	3.06	*Phenylalanine, tyrosine & tryptophan biosynthesis	2.52	Propanoate metabolism	−2.5
CD40L Signaling Pathway	3.03	*Cholera	2.51	Lysine degradation	−2.51
Hematopoietic cell lineage	3.03	*Glutamate metabolism	2.51	Porphyrin and chlorophyll metabolism	−2.61
Pyruvate metabolism	3.03	Alkaloid biosynthesis I	2.49	Carbon fixation	−2.62
ECM-receptor interaction	3.02	Pathogenic Escherichia coli infection	2.49	Citrate cycle (TCA cycle)	−2.63
Olfactory transduction	3.01	Acute myeloid leukemia	2.48	Axon guidance	−2.64
Neuroactive ligand-receptor interaction	2.99	Stilbene, coumarine and lignin biosynthesis	2.48	*gamma-Hexachlorocyclohexane degradation	−2.64
Glycan structures - biosynthesis 1	2.98	Reductive carboxylate cycle (CO2 fixation)	2.47	*Leukocyte transendothelial migration	−2.7
Chondroitin sulfate biosynthesis	2.96	Alanine and aspartate metabolism	2.44	*D-Glutamine and D-glutamate metabolism	−2.73
Folate biosynthesis	2.96	GnRH signaling pathway	2.42	Cytokine Inflammatory Response	−2.77
Pentose and glucuronate interconversions	2.93	*Pyrimidine metabolism	2.41	*Cell cycle	−2.81
*Galactose metabolism	2.92	Parkinson's disease	2.39	Tetrachloroethene degradation	−2.82
Jak-STAT signaling pathway	2.91	Methionine metabolism	2.37	Oxidative phosphorylation	−2.88
Arachidonic acid metabolism	2.9	Bile acid biosynthesis	2.36	microtubule-associated protein 1A	−3.3
*Protein export	2.89	Peptidoglycan biosynthesis	2.36	*Thiamine metabolism	−3.3
Endometrial cancer	2.86	*Valine, leucine and isoleucine degradation	2.36
Regulation of actin cytoskeleton	2.86	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis	2.35
Toll-like receptor signaling pathway	2.85	*MAPK signaling pathway	2.35
Butanoate metabolism	2.84	*Prostate cancer	2.35
C5-Branched dibasic acid metabolism	2.84	*Bladder cancer	2.33
Glycine, serine and threonine metabolism	2.84	Inositol phosphate metabolism	2.33
Adipocytokine signaling pathway	2.83	*Novobiocin biosynthesis	2.33
Glycolysis/Gluconeogenesis	2.82	*Monoterpenoid biosynthesis	2.32
*Glycerolipid metabolism	2.8	*Apoptosis	2.3
Calcium signaling pathway	2.78	Thyroid cancer	2.29
Purine metabolism	2.77	Regulation of autophagy	2.28
Synthesis and degradation of ketone bodies	2.76	Arginine and proline metabolism	2.26