|
MAPK1
|
mitogen-activated protein kinase 1 |
a gene encoding a member of the MAP kinase family known as extracellular signal-regulated kinases (ERKs) which act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development |
| 2) CTNNB1
|
catenin beta 1 |
a gene encoding a protein necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells and also anchors the actin cytoskeleton |
|
ERBB2
|
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 |
encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases; |
|
PARD3
|
par-3 partitioning defective 3 homolog |
gene encodes an adapter protein involved in asymmetrical cell division and cell polarization processes and plays a central role in the formation of epithelial tight junctions |
|
ACTN2
|
actinin, alpha 2 |
encodes a cytoskeletal protein that anchors actin to a variety of intracellular structures |
|
CLDN7
|
claudin 7 |
encodes a member of the claudin family which includes integral membrane proteins and components of tight junction strands that serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets and also play critical roles in maintaining cell polarity and signal transductions |
|
ACTB
|
actin, beta |
encodes an actin protein involved in cell motility Structure and integrity and is a major constituent of the contractile apparatus |
|
CSNK2B
|
casein kinase 2 |
gene encodes a beta subunit of casein kinanse II, a serine/threonine protein kinase that is thought to have a regulatory function in cell proliferation, cell differentiation, and apoptosis and also thought to influence Wnt Signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via the phosphorylation of Akt |
|
GNAI3
|
guanine nucleotide binding protein (G protein) |
gene encodes a protein that is a membrane bound GTPase that is linked to 7-TM receptors |
|
MAP2K1
|
mitogen-activated protein kinase kinase 1 |
gene encodes a protein that is a member of the dual specificity protein kinase family which acts as a mitogen-activated protein (MAP) kinase kinase and is an integration point for multiple biochemical signals |
|
TCF7L1
|
transcription factor 7-like (T-cell specific HMG-box) |
a transcription factor activated by beta catenin and known to mediate the Wnt Signaling pathway |
|
SRC
|
v-src sarcoma viral oncogene |
encodes the tyrosine-protein kinase protein that plays a role in cell growth. According to the Adherens Junction Bayesian network model the gene relationship SRC->RAC1. RAC1 gene expression was suppressed across all three phases. RAC1 (ras-related C3 botulinum toxin substrate 1 rho family small GTP binding protein Rac1) encodes a GTPase protein belonging to the RAS superfamily of small GTP-binding proteins that regulate a diverse array of cellular events including the control of cell growth cytoskeletal reorganization and the activation of protein kinases |
