Skip to main content
. 2012 Aug 17;7(8):e42127. doi: 10.1371/journal.pone.0042127

Table 6. Key Down-Regulated Mechanistic Genes for Cell Adhesion and Integrin-Mediated Cell Adhesion Pathways.

ITGB1 integrin, beta 1 (fibronectin receptor) encodes an integrin membrane receptor involved in cell adhesion and a number of processes including immune response
PTK2 protein tyrosine kinase 2 encodes cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions
MAP2K1 mitogen-activated protein kinase kinase 1 encodes a member of the dual specificity protein kinase family that lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals
SELL selectin L (lymphocyte adhesion molecule 1 encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors
MAPK1 mitogen-activated protein kinase 1 a gene encoding a member of the MAP kinase family known as extracellular signal-regulated kinases (ERKs) which act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development
Mpzl1 myelin protein zero-like 1 encodes a cell surface receptor and is believed to be involved in regulation of integrin-mediated cell motility
CD99 CD99 molecule encodes a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway
ITGA4 integrin, alpha 4 encodes an integrin alpha chain family protein integral to the membrane and known to be involved in cellular adhesion/aggregation processes
CLDN7 claudin 7 encodes a member of the claudin family which includes integral membrane proteins and components of tight junction strands that serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets and also play critical roles in maintaining cell polarity and signal transductions