| Blood samples from four MAP exposed and four unexposed cattle |
Unconfirmed association between MAP exposure and in-vivo MHC gene modulation |
[83]
|
| In silico analysis, for a population-based genetic association of a Spanish Holstein-Friesian sample |
3 tightly linked SNP in TLR4 were found to be associated with susceptibility to MAP infection |
[84]
|
| Early paucibacillary MAP infection compared to multibacillary MAP infection in sheep |
Lower expression levels of most TLRs in paucibacillary group than the multibacillary group |
[85]
|
| MAP infected monocyte-derived dendritic cells |
Unable to present antigen via MHC class II |
[82]
|
| In vitro infection of Chinese Hamster Ovary (CHO) cells with MAP |
Low TLR4 |
[81]
|
| Peripheral blood derived macrophages from juvenile sheep |
Down-regulation of MHC class I and II |
[80]
|
| Bovine macrophages infection (in-vitro) with MAP |
Down-regulation of MHC class I and class II molecules |
[86]
|
| Intestinal macrophages in clinically infected sheep compared with normal tissues |
Lower expression of MHC class II |
[79]
|
